ASSOCIATION OF CD14 (C-159T) GENE POLYMORPHISM AND IRRITATED INTESTINE SYNDROME WITH OBESITY

The purpose of the study – to association polymorphic variant C-159Tof CD14 gene in patients with irritable bowel syndrome (IBS) depending on thepredominance diarrhea or constipation clinical course and relationshipbetween genotypes (C-159T) some blood parameters.Material methods. involved 90 IBS (30 men 60women aged 22 56 years). CD 14 (C-159T)was analyzed by polymerase chain reaction without withconcomitant obesity 30 people comparison group. Blood levels C-reactiveprotein (CRP), tumor necrosis factor α (TNFα), transforming growth β1(TGFβ1), interleukin-10 (IL-10), 8-isoprostane, ceruloplasmin, medium molecules andcalprotectin feces were determined.Results. In obesity, frequency TT genotype (36.7%) washigher compared healthy subjects (TT 13.3%). Significantly higherserum CRP (3.5 times 26.7%), TNFα (1.7 19.5%), TGFβ1(29.8% 19.2%), 8-isoprostane (54.1% 31.9%), ceruloplasmin (56.7% and33.0%), (7, 5% 12.9%) calprotectin (55.7% 37.4%) inthe CC CT have been determined withIBS, combined a predominance diarrhea.Conclusions. withthe risk development obese has established. ischaracterized higher content proinflammatory cytokines lower levelsof anti-inflammatory increased CRP, more pronounced changesin prooxidant antioxidant systems (higher andceruloplasmin, local inflammation (increase content) severity ofendotoxicosis molecules).